【Objective】To observe the difference of type 2 innate lymphoid cells（ILC2）in allergic and non-allergic asthma，and to investigate the relationship between ILC2 and other major clinical parameters.【Methods】Asthma patients came from the First Affiliated Hospital of Sun Yat-sen University from June 2017 to January 2018. Clinical baseline data were collected and levels of asthma severity were assessed. Besides，blood routine and lung function were examined. ILC2 were detected via flow cytometry. Total IgE，sIgE，and Th2 cytokines were quantitated via ELISA and Multiple Cyto? kine Detection System，respectively.【Results】The percentage of ILC2 in lymphoid cells and the number of ILC2 were cor? relate with EOS and sIgE positively，respectively（r=0.37，0.32，0.56，0.57；P<0.01~=0.04）. The percentage and the number of ILC2 in allergic asthma group were 0.04（0.03~0.11）% and 338（255~778）cells/mL，which were both higher than 0.01（0.01~0.02）% and 89（0~169）cells/mL in non-allergic asthma group（P<0.01）. The percentage of ILC2 was （0.10±0.08）% in moderate and severe patients，which was more than（0.04±0.01）% in intermittent and mild patients（P= 0.04）. The percentage and the number of ILC2 were correlate with FEV1/FVC negatively（r=-0.61，P<0.01；r=-0.56，P= 0.01）.【Conclusions】ILC2 participate in pathogenesis of allergic asthma and correlate with EOS，allergy and level of asth? ma severity，which would be an evaluation indicator of allergic asthma and provide a new direction in asthma therapy.