【Objective】To investigate clinical effect of bone cement distribution of“inverted U”style in the injured vertebral body in percutaneous vertebroplasty（PVP）procedure.【Methods】From June 2009 to August 2016，the patients who underwent PVP using low-viscosity cement for treating single vertebral fracture were reviewed in our hospital. The patients were divided into two groups according to CT and X-ray image of bone cement distribution. Group A：bone cement was presented as a complete“inverted U”type in the vertebral body（the bone cement was interconnected at the anterior edge of vertebral body）；group B：A complete“inverted U”type distribution was unformed（the bone cement was not interconnected at the anterior edge of vertebral body）. The data about visual analogue scale（VAS），Oswestry Disability Index（ODI）and Cobb angle before operation，at the 3rd day after operation，and at the final follow-up were collected and evaluated. Adjacent vertebral fracture was also evaluated during the follow-up.【Results】Eighty-three patients who had PVP procedures with low-viscosity cement，including 37 vertebrae with“inverted U”type distribution and 46 vertebrae with incomplete“inverted U”type distribution，were reviewed in our study. The follow-up was 1 to 2 years. The patients′ pain in both groups were obviously relieved at the 3rd day after operation（P<0.05）. The VAS in the A group was more lower than that in the B group（P<0.05）. There was no difference at the final follow-up between the two groups（P>0.05）. A similar result occurred for ODI between them. The Cobb angle at the post-operation 3rd day in both groups significantly improved compared with that at the pre-operation（P<0.05）. There was no obvious loss for Cobb angle at the final follow-up in the two groups（P>0.05）. The number of patients with adjacent vertebral fracture occurred in the A and B group were 2 and 4，respectively（P>0.05）.【Conclusions】The“inverted U”distribution of bone cement in the vertebral body is one of the factors that affect the clinical effect of PVP，especially rapid pain relief. In addition，it is very important in the filling of bone cement for the lateral walls and anterior column，and this is an important factor to prevent re-collapse of cemented vertebral body.