Abstract: 【Objectives】 To determine the treatment effect of the proton pump inhibitor to the LPRD disease. 【Methods】 75 LPRD patients with suspected symptoms were enrolled allocated into 2 comparative groups which included the control group(n=38) taking Lanqin oral medicine treatment and experimental group (n=37) taking Esomeprazole magnesium enteric-coated tablets plus Lanqin oral medicine. Symptoms in the RSI and RFS scales were scored accordingly and post-treatment improvements in week 4 and week 8 were analyzed between the control and experimental groups. 【Results】 9 subjects were excluded due to non-complicance with medicine regimen or follow-up investigations

66 patients were included in the study for the allocation of 35 subjects in the experimental group and 31 subjects in the control group. According to RSI scales

pre-treatment the patients suffered clearing throat (87.88%)

excess throat mucus (86.34%) and globus sensation (90.91%). According to RFS scales

the erythema hyperemia

ventricular obliterans mucous

membrane edema of larynx and vocal fold edema were the most common signs in the patients with the proportions of 95.45%

87.88%

87.88% and 83.33% respectively. The granuloma was only 1.51%. The post-treatment RSI and RFS scores of experimental group in week 4 were 11.54±5.33 and 8.51±2.20

which were different when compared with the pre-treatment scores(P = 0.000

P = 0.0000). The post-treatment RSI was 15.20±6.85

which was no much improvement in the control group(P=0.278)

the RFS scores was 9.90±2.65

slightly declined (P=0.011). The major symptoms and signs were improved in the two group in the week 8 of post-treatment. Esomeprazole group improved better than the control group

the RSI and RFS scores were significant difference(P < 0.05). 【Conclusions】 Proton pump inhibitor could be first hand option for LPR as it could improve the symptom and characteristics faster and significant