Abstract: 【Objective】 To investigate the effect of angiogenesis in peri-infarct area of the placental growth factor therapy for acute myocardial infarction rats and its cardioprotective activity. 【Method】 The AMI rats model was established by ligation of the left anterior descending of coronary arteries. Thirty male Sprague-Dawley rats were randomly divided into three groups: sham group

normal saline group (control group) and PlGF group. Four weeks after ligation and treatment

cardiac function

scar area

plasma concentration of BNP

angiogenesis and arteriogenesis

myocardial collagen I protein expression were studied. Echocardiography

Masson staining

enzyme-linked immunosorbent assay

immunohistochemistry

Western Blot were performed. 【Result】 Four weeks after ligation

compared with the control group

LVEF

LVFS were higher in PlGF group

While LVEDD and LVESD decreased obviously (P < 0.01). Average scar percentage and plasma concentration of BNP were lower in P1GF group (P < 0.01). The mean CD31-positive microvessels and α-SMA positive microvessels of the peri-infarct area were higher in PlGF group (P < 0.01)

while collagen I protein content was decreased in this group (P < 0.01). 【Conclusion】 PlGF intervention improves cardiac function and reduces infarction size in AMI rats

the possible mechanism is related to dual function of promoting angiogenesis and arteriogenesis

reducing collagen I expression is also one of the important mechanisms.