【Objective】 To study the effects of inhaled nitric oxide (iNO) on iNOS (inducible nitric oxide synthase)

IL-1β (interleukin-1β) and IL-6 (interleukin-6) of lung tissue in rats with acute lung injury post liver transplantation. 【Methods】 Twenty-four SD rats were randomly divided into three groups: 1) a sham-operation control group (C group)

the abdomen was only opened and then closed besides the liver lobes were isolated

without NO inhalation. 2) an autologous OLT group (M group)

received autologous OLT

without NO inhalation. 3) an iNO group (T group)

received autologous OLT

with 20 × 10-6 NO inhalation. The lung was removed at 8 h after operation and pathological changes were observed. The concentration of iNOS

IL-1β

and IL-6 in lung tissue were respectively examined in each group

lung wet -to- dry weight ratio (W/D) were also measured. 【Results】 (1) The lung pathological section of C group was normal

but in M group it showed inflammatory injury. The lung inflammatory injury was improved in T group. (2) Lung dry-to-wet weight ratio in M group was higher than in C group. It decreased in T group

but still higher than in C group. (3) The levels of iNOS

IL-1β

and IL-6 in M group were higher than in C group. All decreased in T group

but still higher than in C group. The expression of iNOS showed the same change. 【Conclusion】 Inhaled NO after autologous OLT inhibits the activity of iNOS in lung

decreases the production of IL-1β and IL-6

attenuates pathological changes

and decreased lung wet -to- dry weight ratio.