【Objective】 To investigate the multiple characteristics of fetal malformation in prenatal diagnosis and its relationship with chromosomal abnormalities. 【Methods】 A total of 853 cases were divided into multiple malformations group (n = 103) and non-malformation group (control group

n = 750) according to ultrasound detected multiple malformations or not. Collecting clinical data: the discovery of fetal malformations time

the number of deformities

the abnormal types and rates of chromosome abnormalities and outcomes of karyotypes associated malformations. 【Results】 Comparing the results of two groups

the fetal chromosomal abnormality rate (multiple malformations group 43.69%

0.93% in control group)

the sex ratio (multiple malformations group 1.94

control group 0.97)and the prenatal diagnosis of gestational age [multiple malformations group (25 ± 5) weeks

the control group (21 ± 4) weeks] were significant differences. The more the number of fetal malformations found by ultrasound

the greater the risk of fetal chromosomal abnormality (r = 0.792

P = 0.017).Multivariate statistical analysis of the results suggest that ultrasound detection of fetal face and neck abnormalities(OR = 7.748

P = 0.000)

cardiovascular abnormalities(OR = 5.064

P = 0.002)

urinary tract abnormalities (OR = 0.195

P = 0.005)

and single umbilical artery (OR = 4.608

P = 0.020)related to fetal chromosomal abnormalities in multiple malformation fetuses.【Conclusion】 Multiple malformations showed higher rate of fetal chromosomal abnormalities. Cardiovascular abnormality

face and neck abnormalities and single umbilical artery may be used as a predictor of fetal chromosomal abnormalities.