【Object ive】To observe the relationship between Vitamin D receptor (VDR)genoty pe and bone mineral densi ty in pre- and postmenopausal w omen .【Methods】Seventy-eight postmenopausal women w ithout fragile fractures

34 postmenopausal w omen wi th f ragile f ractures

20 peri-menopausal w omen w ith climacteric symptoms

and 52 healthy y oung w omen (aged 25 ～ 35 years)were enrolled the study .Bo ne mineral density w as measured by dual energy X-ray absorptiometry (DEXA)at lumbar spine

proximal femur

forearm and total body .We also ex amined the restriction fragment length polymo rphism of the polymerase chain reaction product (PCR-RFLPs)of the VDR gene w ith BsmI enzyme (B

absence

b

presence of cut site)in these women .【Result 】In 184 w omen

the dist ribution of BsmI RFLPs w as as follow :BB

14(7.6 %);Bb

83(45.1 %);bb

96 (47.2 %);respectively .The bone mineral densi ty in healthy y oung women w as not sig nificant ly different among the three genotypes g roups .The bone mineral density in postmenopausal women and the ratio of postmenopausal osteoporosis were also not signif icantly dif ferent among the three genotypes g roups .【Conclusion】 These data indicated no sig nificant ef fects of the VDR genoty pes def ined by BsmI on female peak bone mineral densi ty and postmenopausal osteoporosis .