1.河南中医药大学康复医学院,河南 郑州 450046
2.河南中医药大学第一附属医院康复中心,河南 郑州 450000
刘楠楠,第一作者,研究方向:脑卒中,E-mail:15083279917@163.com
收稿:2025-10-08,
修回:2025-11-10,
录用:2025-12-30,
纸质出版:2026-01-20
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刘楠楠,冯晓东.类泛素化修饰在缺血性脑卒中的机制及潜在治疗靶点[J].中山大学学报(医学科学版),2026,47(01):84-94.
LIU Nannan,FENG Xiaodong.The Mechanism and Potential Therapeutic Targets of SUMOylation in Ischemic Stroke[J].Journal of Sun Yat-sen University(Medical Sciences),2026,47(01):84-94.
刘楠楠,冯晓东.类泛素化修饰在缺血性脑卒中的机制及潜在治疗靶点[J].中山大学学报(医学科学版),2026,47(01):84-94. DOI: 10.11714/jsysu.med.YX20250147.
LIU Nannan,FENG Xiaodong.The Mechanism and Potential Therapeutic Targets of SUMOylation in Ischemic Stroke[J].Journal of Sun Yat-sen University(Medical Sciences),2026,47(01):84-94. DOI: 10.11714/jsysu.med.YX20250147.
缺血性脑卒中(IS)是全世界第二大死亡原因,具有高发病率与高致残率的特点。类泛素小分子(SUMO)修饰是一种重要的蛋白质翻译后修饰,在IS的发生发展中至关重要。本文从SUMO化修饰调控神经炎症、线粒体动力学、细胞凋亡、氧化应激和血管生成以及总结靶向SUMO化修饰治疗IS潜在靶点等方面,综述SUMO化修饰与IS的关系,为临床治疗IS提供新的方向。
Ischemic stroke (IS) is the second leading cause of death worldwide, characterized by high morbidity and disability rates. Small ubiquitin-related modifier (SUMO) modification, a crucial post-translational modification, plays a vital role in the pathogenesis of IS. This review elucidates the relationship between SUMOylation and IS by detailing how SUMOylation regulates key pathological processes, including neuroinflammation, mitochondrial dynamics, apoptosis, oxidative stress, and angiogenesis. Furthermore, it summarizes potential therapeutic targets of SUMOylation for IS treatment, aiming to provide new directions for clinical management.
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