Advances in the Mechanism of Action of Hydrogel in Repairing Spinal Cord Injury

YANG Yike; REN Yafeng

doi:10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240827.002

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Advances in the Mechanism of Action of Hydrogel in Repairing Spinal Cord Injury

Review | 更新时间：2024-12-23

- Advances in the Mechanism of Action of Hydrogel in Repairing Spinal Cord Injury
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 45, Issue 5, Pages: 785-796(2024)
- 作者机构：
  
  1.河南中医药大学康复医学院，河南郑州 450046
  2.河南中医药大学第一附属医院，河南郑州 450000
- 作者简介：
  
  REN Yafeng； E-mail：253453490@qq.com
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240827.002
  CLC： R459.9;R651.2
- Published：20 September 2024，
  
  Received：10 July 2024，
  
  Accepted：2024-08-26
- 稿件说明：
移动端阅览
杨溢珂,任亚锋.水凝胶修复脊髓损伤作用机制的研究进展[J].中山大学学报（医学科学版）,2024,45(05):785-796.

YANG Yike,REN Yafeng.Advances in the Mechanism of Action of Hydrogel in Repairing Spinal Cord Injury[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(05):785-796.
杨溢珂,任亚锋.水凝胶修复脊髓损伤作用机制的研究进展[J].中山大学学报（医学科学版）,2024,45(05):785-796. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240827.002.

YANG Yike,REN Yafeng.Advances in the Mechanism of Action of Hydrogel in Repairing Spinal Cord Injury[J].Journal of Sun Yat-sen University(Medical Sciences),2024,45(05):785-796. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240827.002.

摘要

脊髓损伤（SCI）是一种病情重、预后差的中枢神经系统疾病，其所导致的严重的感觉、运动或自主神经功能障碍极大地降低了患者的生活质量。尽管SCI的治疗和护理方面已经取得了相当大的进展，但由于药物不能通过血脊髓屏障直接输送到SCI部位，且SCI后的局部微环境不利于植入干细胞的存活、分化和增殖，使SCI的临床疗效及预后并不令人满意。水凝胶因其优异的机械性能、可塑性以及良好的生物相容性和生物降解性，可以作为装载干细胞或药物的递送系统，提供良好的环境并控制其释放，也可以作为生物支架，支持和引导轴突再生，有效提高脊髓损伤的治疗效果。本文综述了水凝胶的分类及功能特性，并进一步讨论了水凝胶在SCI修复中的改善脊髓损伤的抑制性微环境、促进神经再生、促进血管生成、促进血脊髓屏障修复等机制的研究进展，以期为水凝胶治疗SCI的临床应用及未来脊髓再生策略的探索和发展提供理论依据。

Abstract

Spinal cord injury （SCI） is a severe central nervous system disease with poor prognosis， and the resulting severe sensory， motor or autonomic dysfunction greatly reduces patients' quality of life. Although considerable progress has been made in the treatment and care of SCI， the clinical efficacy and prognosis of SCI are not satisfactory due to the inability of drugs to be delivered directly to the site of SCI through the blood-spinal cord barrier and the fact that the local microenvironment after SCI is not conducive to the survival， differentiation， and proliferation of implanted stem cells. Due to its excellent mechanical properties， plasticity， and good biocompatibility and biodegradability， hydrogel can be used as a delivery system for loading stem cells or drugs， providing a favorable environment and controlling their release， and as a biological scaffold to support and guide axonal regeneration， which can effectively improve the therapeutic effect of spinal cord injury. This paper mainly reviews the classification and functional properties of hydrogels， and further discusses the research progress of hydrogels in SCI repair to improve the inhibitory microenvironment of spinal cord injury， promote nerve regeneration， promote angiogenesis， and promote the repair of the blood-spinal cord barrier， with the aim of providing a theoretical basis for the clinical application of hydrogels in the treatment of SCI as well as for exploring and developing future spinal cord regeneration strategies.

关键词

脊髓损伤水凝胶作用机制微环境神经再生

Keywords

spinal cord injuryhydrogelmechanism of actionmicroenvironmentnerve regeneration

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