【Objective】A retrospective analysis was performed to evaluate the reproductive outcome of 64 women with uterine malformation who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and embryo transfer (ET). 【Methods】Database of the First Affiliated Hospital of Sun Ye-sen University were indexed to found patients who with uterine malformation undergo ART from 1 January 2002 to 31 December 2009. Patients were grouped according to the type of uterine malformation and their clinical and laboratory data were be compared. Once the patient was pregnant we followed up until delivery. The miscarriage rate

preterm delivery rate

term delivery rate

weight of newborn

gestation weeks and congenital malformation rate were compared. 【Results】We conducted a retrospective analysis of data from 64 patients with the following types of congenital uterine malformation: 13 arcuate

19 unicomate

18 didelphys

14 subseptate. There were no significant differences in the age

duration of infertility

bFSH

the number of oocytes retrived

fertility rate

cleavage rate

good quality embryo rate when the various types of uterine malformation were compared. Patients with subseptate uterus had significantly higher accumulation pregnant rate compared with patients with arcuate uterus and didelphys uterus (P<0.05). There was no difference in miscarriage rate

preterm delivery rate

take baby home rate

multiple pregnancy rate

weight of newborn

gestation weeks between four groups. There was no ectopic pregnancy and fetal anomaly in each group. 【Conclusion】Clinical pregnancy rate and implantation rate are worse in patients with uterine malformation compare with patients without uterine malformation. Patients with subseptate uterus underwent metroplasty before assisted reproduction had better clinical pregnancy rate compare with patients with arcuate uterus and didelphys uterus.