1.广州市第一人民医院介入医学科,广东 广州 510000
2.中山大学附属第一医院放射介入科,广东 广州 510080
李楠,第一作者,研究方向:肿瘤性疾病的介入治疗,E-mail: zsylinan@163.com
收稿:2026-05-18,
修回:2026-08-28,
录用:2026-08-31,
纸质出版:2026-09-20
移动端阅览
李楠,李乐希,杨建勇等.术前栓塞材料对3 cm以上的Shamblin Ⅱ/Ⅲ型颈动脉体瘤外科手术的影响[J].中山大学学报(医学科学版),2026,47(05):931-937.
LI Nan,LI Lexi,YANG Jianyong,et al.Impact of Preoperative Embolization Materials on Surgery for Sizeable Shamblin Type Ⅱ/Ⅲ Carotid Body Tumors[J].Journal of Sun Yat-sen University(Medical Sciences),2026,47(05):931-937.
李楠,李乐希,杨建勇等.术前栓塞材料对3 cm以上的Shamblin Ⅱ/Ⅲ型颈动脉体瘤外科手术的影响[J].中山大学学报(医学科学版),2026,47(05):931-937. DOI: 10.11714/jsysu.med.YX20260068.
LI Nan,LI Lexi,YANG Jianyong,et al.Impact of Preoperative Embolization Materials on Surgery for Sizeable Shamblin Type Ⅱ/Ⅲ Carotid Body Tumors[J].Journal of Sun Yat-sen University(Medical Sciences),2026,47(05):931-937. DOI: 10.11714/jsysu.med.YX20260068.
目的
2
探讨外科术前经导管动脉栓塞(TAE) 的不同材料对直径>3 cm的Shamblin Ⅱ/Ⅲ型颈动脉体瘤(CBTs)外科切除术的影响。
方法
2
本研究回顾性分析2010年1月至2025年8月我院收治的直径>3 cm且行外科术前TAE的Shamblin Ⅱ/Ⅲ型CBTs患者资料,根据栓塞材料的不同将患者分为两组:非永久栓塞组和永久栓塞组。收集并比较两组患者的一般临床资料、手术方式、介入手术栓塞材料、外科手术出血量、手术时间、主要并发症等相关指标。
结果
2
本研究共纳入50例CBTs患者,共计50个病灶(非永久栓塞组
n
=25,永久栓塞组
n
=25)。非永久栓塞组与永久栓塞组肿瘤大小分别为[(41.22
vs
. 42.13) mm,
P=
0.989]、术中出血量以及手术时间分别为[(388.19
vs
. 155.90) mL,
P
<0.001;(254.01
vs
. 162.22) mins,
P
=0.007]。非永久栓塞组与永久栓塞组术中血管重建率分别为16%和12% (
P
=0.684)、并发症的发生率分别为36%和12% (
P
=0.047)。
结论
2
对于>3 cm Shamblin Ⅱ
/
Ⅲ级 CBTs,应用永久性栓塞材料行TAE,能够显著减少术中出血量、缩短手术用时、提升术野清晰度,从而有助于肿瘤的顺利切除,并降低术后并发症的发生率。
Objective
2
To explore the effects of different embolic materials for preoperative transarterial embolization (TAE) on surgical resections of sizeable (>3 cm) Shamblin Ⅱ/Ⅲ carotid body tumors (CBTs)
Methods
2
This study retrospectively analyzed the data of patients with Shamblin type Ⅱ/Ⅲ carotid body tumors >3 cm in size who underwent TAE at our hospital between January 2010 and August 2025. Based on the adopted embolic agents, the patients were divided into two groups: temporary embolization group (TEG) and permanent embolization group (PEG). General clinical data, periprocedural details, and postoperative outcomes were collected and compared between the two groups.
Results
2
A total of 50 patients with 50 lesions were included (
n
=25 in the TEG and
n
=25 in PEG group). Tumor sizes were comparable between the two groups [(41.22
vs
. 42.13) mm,
P
=0.989]. For the TEG compared with PEG, intraoperative blood loss was (388.19
vs
. 155.90) mL (
P
<0.001) and operative time was (254.01
vs
. 162.22) mins (
P
=0.007). The intraoperative vascular reconstruction rate was 16%
vs
. 12% (
P
=0.684), and the complication rate was 36%
vs
. 12% (
P
=0.047) in the TEG and PEG.
Conclusions
2
Our results indicate that the use of permanent embolic agents during TAE is optimal. These agents are superior to temporary embolic agents in terms of intraoperative blood loss, operative time, and improved surgical field visualization, which thereby facilitate the surgical resection of Shamblin type Ⅱ/Ⅲ CBTs while reducing postoperative complications.
Shiga K , Katagiri K , Ikeda A , et al . Carotid body tumors-epidemiology and surgical resection [J]. Jpn J Clin Oncol , 2025 , 55 ( 8 ): 852 - 859 .
Batarseh P , Li J , Strosberg D . Carotid body tumors [J]. Semin Neurol , 2026 , 46 ( 4 ): 409 - 412 .
Yu J , Yuan W , Cao K , et al . Carotid body tumors: from basic to clinical practice [J]. Vasc Endovascular Surg , 2025 : 15385744251387662 .
Işık M , Kılınç F , Dereli Y , et al . Surgical and histopathological results in carotid body tumors [J]. Thorac Cardiovasc Surg , 2025 , 73 ( 6 ): 434 - 441 .
张强 , 梁国标 , 王晓刚 , 等 . 颈动脉体瘤切除术治疗复杂颈动脉体瘤1例 [J]. 临床军医杂志 , 2022 , 50 ( 1 ): 109 - 110 .
Zhang Q , Liang GB , Wang XG . Surgical resection of carotid body tumor in a complex case [J]. Clin J Med Officers , 2022 , 50 ( 1 ): 109 - 110 .
Schick PM , Hieshima GB , White RA , et al . Arterial catheter embolization followed by surgery for large chemodectoma [J]. Surgery , 1980 , 87 ( 4 ): 459 - 464 .
Liu J , Li Y , Yang L , et al . Surgical resection of carotid body tumors with versus without preoperative embolization: Retrospective case-control study [J]. Head Neck , 2018 , 40 ( 12 ): 2590 - 2595 .
Chen Y , Li Y , Liu J , et al . The clinical characteristics and outcomes of carotid body tumors in Chinese patients: a STROBE-compliant observational study [J]. Medicine , 2020 , 99 ( 3 ): e18824 .
Shiga K , Katagiri K , Ikeda A , et al . Challenges of surgical resection of carotid body tumors-multiple feeding arteries and preoperative embolization [J]. Anticancer Res , 2022 , 42 ( 2 ): 645 - 652 .
Katagiri K , Shiga K , Ikeda A , et al . Effective, same-day preoperative embolization and surgical resection of carotid body tumors [J]. Head Neck , 2019 , 41 ( 9 ): 3159 - 3167 .
Wu Z , Qiu P , Pu H , et al . Efficacy and safety of preoperative embolization in carotid body tumor treatment: a propensity score matching retrospective cohort study [J]. Head Neck , 2022 , 44 ( 6 ): 1414 - 1421 .
Huang X , Wang L , Chen Y , et al . The comparative outcomes of particulate versus coil preoperative embolization for carotid body tumors [J]. Front Oncol , 2022 , 12 : 860788 .
孔祥国 , 李楠 , 杨建勇 , 等 . 术前经导管动脉栓塞对Shamblin Ⅱ/Ⅲ型颈动脉体瘤切除术的影响 [J]. 中山大学学报(医学科学版) , 2021 , 42 ( 2 ): 287 - 293 .
Kong XG , Li N , Yang JY , et al . Beneficial effects of preoperative embolization on the Shamblin type Ⅱ/Ⅲ carotid body tumor surgery [J]. J Sun Yat-Sen Univ (Med Sci) , 2021 , 42 ( 2 ): 287 - 293 .
Li N , Wan Y , Chen W , et al . Beneficial effects of preoperative superselective embolization on carotid body tumor surgery: a 13-year single-center experience [J]. Front Oncol , 2022 , 12 : 930127 .
Li N , Zeng N , Wan Y , et al . The earlier, the better: The beneficial effect of different timepoints of the preoperative transarterial embolization on ameliorating operative blood loss and operative time for carotid body tumors [J]. Surgery , 2021 , 170 ( 5 ): 1581 - 1585 .
Zhang J , Fan X , Zhen Y , et al . Impact of preoperative transarterial embolization of carotid body tumor: a single center retrospective cohort experience [J]. Int J Surg , 2018 , 54 ( Pt A ): 48 - 52 .
Gözen ED , Tevetoğlu F , Kara S , et al . Is preoperative embolization necessary for carotid paraganglioma resection: experience of a tertiary center [J]. Ear Nose Throat J , 2020 : 145561320957236 .
Felbaum DR , Syed HR , McCullough MF , et al . Embolization of carotid body tumors: revisiting direct puncture technique, preliminary experience and literature review [J]. Cureus , 2016 , 8 ( 2 ): e483 .
Abu-Ghanem S , Yehuda M , Carmel NN , et al . Impact of preoperative embolization on the outcomes of carotid body tumor surgery: a meta-analysis and review of the literature [J]. Head Neck , 2016 , 38 ( Suppl 1 ): E2386 - 2394 .
Ashour R , Aziz-Sultan A . Preoperative tumor embolization [J]. Neurosurg Clin North Am , 2014 , 25 ( 3 ): 607 - 617 .
Shamblin WR , ReMine WH , Sheps SG , et al . Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases [J]. Am J Surg , 1971 , 122 ( 6 ): 732 - 739 .
Luna-Ortiz K , Rascon-Ortiz M , Villavicencio-Valencia V , et al . Does Shamblin's classification predict postoperative morbidity in carotid body tumors? a proposal to modify Shamblin's classification [J]. Eur Arch Otorhinolaryngol , 2006 , 263 ( 2 ): 171 - 175 .
Wernick BD , Furlough CL , Patel U , et al . Contemporary management of carotid body tumors in a Midwestern academic center [J]. Surgery , 2021 , 169 ( 3 ): 700 - 704 .
Kaya MG , Romagnoli S , Mandigers TJ , et al . Role of preoperative embolization in surgical management of carotid body tumors: a systematic review and meta-analysis [J]. Angiology , 2025 , 76 ( 1 ): 17 - 31 .
Power AH , Bower TC , Kasperbauer J , et al . Impact of preoperative embolization on outcomes of carotid body tumor resections [J]. J Vasc Surg , 2012 , 56 ( 4 ): 979 - 989 .
Lim JY , Kim J , Kim SH , et al . Surgical treatment of carotid body paragangliomas: outcomes and complications according to the shamblin classification [J]. Clin Exp Otorhinolaryngol , 2010 , 3 ( 2 ): 91 - 95 .
Texakalidis P , Charisis N , Giannopoulos S , et al . Role of preoperative embolization in carotid body tumor surgery: a systematic review and meta-analysis [J]. World Neurosurg , 2019 , 129 : 503 - 513.e502 .
Lamblin E , Atallah I , Reyt E , et al . Neurovascular complications following carotid body paraganglioma resection [J]. Eur Ann Otorhinolaryngol Head Neck Dis , 2016 , 133 ( 5 ): 319 - 324 .
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621
