遵义医科大学附属医院神经内科,贵州 遵义 563000
周弘艳,第一作者,研究方向:酒精中毒性神经系统疾病,E-mail:542431090@qq.com
收稿:2026-01-08,
修回:2026-04-18,
录用:2026-04-23,
纸质出版:2026-05-20
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周弘艳,徐平.菌群-肠-脑轴在酒精性脑损伤中的研究进展[J].中山大学学报(医学科学版),2026,47(03):419-428.
ZHOU Hongyan,XU Ping.Research Advances on the Microbiota-gut-brain Axis in Alcohol-related Brain Injury[J].Journal of Sun Yat-sen University(Medical Sciences),2026,47(03):419-428.
周弘艳,徐平.菌群-肠-脑轴在酒精性脑损伤中的研究进展[J].中山大学学报(医学科学版),2026,47(03):419-428. DOI: 10.11714/jsysu.med.YX20260008.
ZHOU Hongyan,XU Ping.Research Advances on the Microbiota-gut-brain Axis in Alcohol-related Brain Injury[J].Journal of Sun Yat-sen University(Medical Sciences),2026,47(03):419-428. DOI: 10.11714/jsysu.med.YX20260008.
长期酗酒作为全球范围内的公共卫生问题,已严重危害人体健康。酒精滥用通过多途径破坏人体多个器官和系统的功能。易受酒精影响的菌群-肠-脑轴在体内稳态、免疫成熟、内分泌代谢等方面起着至关重要的作用。长期过量饮酒不仅改变肠道菌群的组成和代谢物水平,还破坏肠道屏障的完整性,增加肠道通透性,使得有害代谢物进入血液循环,进而引发包括酒精性脑损伤在内的多种疾病。酒精性脑损伤是酒精使用障碍(AUD)未被识别或未得到有效治疗的严重后果之一,可导致广泛的神经损伤和神经认知功能障碍。尽管菌群-肠-脑轴在酒精性脑损伤中的潜在作用已被提出,但目前仍未明确其具体机制。因此,在本综述中,我们对长期酗酒、菌群-肠-脑轴和酒精性脑损伤之间的关联进行了分析,并探讨酒精通过该轴引发脑损伤的潜在机制。
Chronic excessive alcohol consumption is a major global public health concern that severely endangers human health. Excessive alcohol intake disrupts the functions of multiple organs and systems in the human body through diverse mechanisms. The alcohol-sensitive microbiota-gut-brain axis plays a critical role in maintaining systemic homeostasis, immune maturation, and endocrine metabolism. Chronic excessive alcohol consumption not only alters the composition of the gut microbiota and the levels of its metabolites, but also compromises intestinal barrier integrity, increases intestinal permeability, and allows harmful metabolites to enter the systemic circulation, thereby triggering a variety of diseases including alcohol-related brain injury. Alcohol-related brain injury is one of the most severe consequences of unrecognized or inadequately treated alcohol use disorder (AUD), which can lead to extensive neuronal damage and neurocognitive dysfunction. Although the potential role of the microbiota-gut-brain axis in alcohol-related brain injury has been proposed, the exact underlying mechanisms have not yet been fully elucidated. Therefore, in this review, we systematically analyze the associations among chronic excessive alcohol consumption, the microbiota-gut-brain axis, and alcohol-related brain injury, and explore the potential mechanisms underlying alcohol-induced brain damage via this axis.
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