Increased Aneuploidy Rates and Euploid-Embryo-Transfer Miscarriage Rates in PCOS Patients

LIU Xinran; JIE Huiying; SU Shanni; ZHOU Canquan

doi:10.11714/jsysu.med.YX20260039

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Increased Aneuploidy Rates and Euploid-Embryo-Transfer Miscarriage Rates in PCOS Patients

更新时间：2026-04-16

- Increased Aneuploidy Rates and Euploid-Embryo-Transfer Miscarriage Rates in PCOS Patients
- Journal of Sun Yat-sen University(Medical Sciences) Pages: 1-10(2026)
- 作者机构：
  
  中山大学附属第一医院妇产科生殖医学中心，广东广州 510080
- 作者简介：
  
  ZHOU Canquan ； E-mail： zhoucanquan@mail.sysu.edu.cn
- 基金信息：
- DOI：10.11714/jsysu.med.YX20260039
  CLC： R711.6
- Received：14 March 2026，
  
  Revised：2026-04-08，
  
  Accepted：12 April 2026，
  
  Online First：16 April 2026，
- 稿件说明：
移动端阅览
LIU Xinran, JIE Huiying, SU Shanni, et al. Increased Aneuploidy Rates and Euploid-Embryo-Transfer Miscarriage Rates in PCOS Patients[J/OL]. Journal of Sun Yat-sen University(Medical Sciences), 2026, 1-10.
DOI：

LIU Xinran, JIE Huiying, SU Shanni, et al. Increased Aneuploidy Rates and Euploid-Embryo-Transfer Miscarriage Rates in PCOS Patients[J/OL]. Journal of Sun Yat-sen University(Medical Sciences), 2026, 1-10. DOI： 10.11714/jsysu.med.YX20260039.

摘要

目的

探讨多囊卵巢综合征（PCOS）患者囊胚染色体特征及其妊娠结局，分析PCOS对胚胎非整倍体率及流产风险的影响。

方法

采用回顾性队列研究，纳入中山大学附属第一医院行胚胎植入前遗传学检测（PGT）中非整倍体检测（PGT-A）及单基因遗传病检测（PGT-M）的周期，通过倾向评分匹配筛选出191个PCOS组周期与564个对照组周期。比较两组卵母细胞及胚胎发育潜力、囊胚染色体检测结果及临床结局。根据获卵数将PCOS患者分为>20枚组和≤20枚组，比较不同卵巢反应水平下整倍体胚胎移植后的妊娠结局。

结果

PCOS组囊胚非整倍体率高于对照组（21.8%

. 19.0%，

=0.044）。PCOS组总体流产率高于对照组（16.6%

. 10.3%，

=0.039）。移植整倍体胚胎后，PCOS组流产率仍高于对照组（17.2%

. 10.0%，

=0.019）。亚组分析显示，获卵数

20枚的PCOS患者移植整倍体胚胎后的流产率高于对照组（21.4%

. 6.7%，

=0.001），早期流产率亦升高（15.7%

. 5.7%，

=0.011）；而获卵数≤20枚亚组与对照组临床结局差异无统计学意义。

结论

PCOS患者囊胚非整倍体率较对照组显著升高。PCOS患者囊胚移植流产率，甚至整倍体囊胚流产率均较对照组显著增加，尤其表现在高卵巢反应PCOS患者中。

Abstract

Objective

To investigate the chromosomal characteristics of blastocysts and pregnancy outcomes in patients with polycystic ovary syndrome （PCOS）， and to analyze the impact of PCOS on embryonic aneuploidy rate and the risk of miscarriage.

Methods

The retrospective cohort study was conducted on the preimplantation genetic testing（PGT） in the First Affiliated Hospital of Sun Yat-sen University， including cycles of PGT for aneuploidy（PGT-A） and PGT for monogenic disorders（PGT-M）. The 191 PCOS cycles（PCOS group） were matched with 564 control cycles（control group） using propensity score matching. The oocyte and embryo viability， chromosomal testing results of blastocysts， and cumulative clinical outcomes were compared between two groups. Subgroup analysis was performed by stratifying PCOS patients based on oocyte retrieval （

. ≤20）. And the pregnancy outcomes after euploid embryo transfer were compared under different levels of ovarian response.

Results

PCOS group showed a significantly higher rate of aneuploidy per blastocyst compared to control group （21.8%

. 19.0%，

=0.044）. Clinically， the overall miscarriage rate in the PCOS group was significantly higher than control group （16.6%

. 10.3%，

=0.039）， even after euploid embryo transfer （17.2%

. 10.0%，

=0.019）. In the PCOS subgroup with

20 oocytes ， the miscarriage rate following euploid embryo transfer was dramatically increased compared to control group （21.4%

. 6.7%，

=0.001）， accompanied by higher risks of early miscarriage （15.7%

. 5.7%，

=0.011）. Conversely， the PCOS subgroup with ≤ 20 oocytes showed outcomes comparable to control group.

Conclusions

Patients with PCOS exhibit a significantly higher rate of blastocyst aneuploidy compared to the control group. Furthermore， PCOS is associated with a marked increase in miscarriage rates following blastocyst transfer， even with euploid embryos， particularly among patients with high ovarian response.

关键词

Keywords

references

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Reproductive Medicine Research Center， The Sixth Affiliated Hospital of Sun Yat-sen University // Guangdong Engineering Technology Research Center of Fertility Preservation

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Department of Obstetrics and Gynecology，Sun Yat-Sen Memorial Hospital

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